Host Genome x Diet Interaction QTL Database 1.0.

The database is the interface to Jbrowse which enables visualization of host genome (Mus Musculus) QTL and its interaction with diet regulating various physiological and patho-physiogical phenotypes.

The interface also provides SNPs and INDELs from four founder strains i.e. BxD2/TyJ, NZM2410/J, CAST/EiJ and MRL/MpJ for fine-mapping QTL to candidate genes.

AIL Mice Suggestive QTL Table

The table enumerates chromosome-wide QTL (p < 0.05) in AIL mice.

Phenotype CHR SNP Pos Start End LOD Model
Weight 6M (g)18UNC2949795367.7267.21868.5124.266Additive
Weight 2M (g)10backupUNC100253553115.816115.16115.8924.841Additive
Weight 2M (g)11UNC2011998591.25891.17191.3094.708Additive
Weight 2M (g)12UNC2073034021.59910.66824.415.263Additive
Weight 2M (g)16JAX0007010159.85759.81959.9224.015Additive
Steatosis5UNC892284333.42133.24434.8285.417Additive
Ballooning16JAX0007193684.50584.45884.5535.539Additive
Eosinophils (K/μL)XUNC31179228106.112103.528107.4674.167Additive
Basophils (K/μL)2UNC24669893.1823.1644.4524.712Additive
Basophils (K/μL)12UNC2061854710.67610.66810.6964.125Additive
Basophils (K/μL)19UNC3052525554.76554.42854.9944.127Additive
Eosinophils (%)3UNC5899453105.422105.293105.4255.308Additive
G0 (%)11JAX0019810749.45648.83449.8084.188Additive
G0 (%)17UNC2779849733.93932.80635.0934.211Additive
G1 (%)12UNC21926579113.73113.194113.8845.104Additive
Galactose (%)17UNC2779849733.93932.84335.0935.036Additive
bi-Galactose (%)17UNC2779399133.38932.31135.1944.196Additive
IgA/IgM14UNC24940559124.333122.863124.7694.26Additive
IgG/IgM12UNC2148032680.64980.11782.1233.947Additive
IgG/IgM18UNC2890419324.98224.50925.3974.395Additive
Weight 6M (g)2UNC3946576128.784128.373128.984.886Diet
Weight 6M (g)3UNC6560662152.937138.123153.0425.483Diet
Weight 6M (g)6UNC1151862685.0024.019145.2824.697Diet
Weight 6M (g)8CEAJAX0015927617.03816.76419.2514.64Diet
Weight 6M (g)12backupJAX0033359052.1751.99252.7694.364Diet
Weight 6M (g)14UNC2429688577.47576.41378.0434.631Diet
Cholesterol (mg/dl )9UNC1604502827.4422.3128.1594.906Diet
Cholesterol (mg/dl )14UNC2423300073.00771.89673.4884.344Diet
LDL (mg/dl)7UNC13808684127.078125.899132.8254.13Diet
LDL (mg/dl)9UNC1604994127.86127.57528.1594.694Diet
LDL (mg/dl)16UNC2723952781.72280.83783.8244.218Diet
LDL (mg/dl)18UNC2936281459.20258.38860.6074.332Diet
Weight 2M (g)1UNC86535868.5968.14469.6134.557Diet
Weight 2M (g)2UNC324465967.27965.94867.8774.894Diet
Weight 2M (g)4UNC719087747.38247.252142.6744.904Diet
Weight 2M (g)10JAX0028685632.83428.31672.2335.005Diet
Weight 2M (g)11JAX0002507420.4615.36121.5314.156Diet
Weight 2M (g)15UNC26247720103.63693.879103.6364.487Diet
Weight 2M (g)16JAX000660956.4245.78612.4355.21Diet
Weight 2M (g)18UNC2907365238.54311.94838.924.828Diet
Weight 2M (g)XJAX0071391975.13271.19182.2194.766Diet
Weight 4M (g)2UNC3946248128.76465.913129.2574.398Diet
Weight 4M (g)6UNC104717444.0274.019144.9864.904Diet
Weight 4M (g)8UNC1424689416.81915.1119.2424.328Diet
Weight 4M (g)11UNC1921492420.33819.53663.0824.649Diet
Weight 4M (g)14JAX0038438175.63875.33278.0434.343Diet
Weight 4M (g)18UNC2907365238.54325.30838.6934.644Diet
Weight 6M (g)2UNC3946576128.784128.373128.984.323Diet
Weight 6M (g)6UNC12298596144.486144.389144.9864.701Diet
Weight 6M (g)8CEAJAX0015927617.03816.76419.2514.798Diet
Weight 6M (g)11JAX0031039749.11546.98462.775.362Diet
Weight 6M (g)12backupJAX0033359052.1751.89352.7694.451Diet
Weight 6M (g)14UNC2429688577.47576.37578.0434.318Diet
Steatosis8UNC1423128516.01515.40317.024.781Diet
Steatosis11UNC189949554.1453.35816.2684.298Diet
Steatosis13UNC2212966211.79110.43916.0374.033Diet
Steatosis14UNC2431181178.49278.27883.1575.056Diet
Steatosis17UNC2773087128.06128.00631.6763.972Diet
Steatosis19UNC3029162838.55538.39438.6974.589Diet
Ballooning6UNC1110621153.95953.66154.1584.22Diet
Ballooning14UNC2366149020.19317.91320.9024.055Diet
NAFLD8JAX0066210016.48215.66217.1134.271Diet
NAFLD9UNC09074663333.43532.46233.4794.476Diet
NAFLD11JAX0030817436.68636.13137.0734.159Diet
NASH4UNC8383363142.319141.496142.6235.347Diet
NASH7UNC1245065616.39913.02216.6734.977Diet
NASH8UNC1424142316.5584.47116.8195.341Diet
NASH9UNC1586672713.66213.13614.25.025Diet
NASH17UNC2773087128.06128.00629.774.667Diet
CRP (pg/ml)1UNC79264962.85362.55363.3165.179Diet
Lymphocytes (K/μL)9UNC17198230116.023115.949116.5365.309Diet
Lymphocytes (K/μL)10JAX0001836057.5756.75358.6363.99Diet
Monocytes (K/μL)3UNC481361019.5116.78719.7465.109Diet
Monocytes (K/μL)6UNC11767408104.977102.111085.116Diet
Monocytes (K/μL)7JAX00157728138.663138.071138.8643.964Diet
Monocytes (K/μL)10JAX0001835857.5353.25761.1054.191Diet
Eosinophils (K/μL)8UNC15746498128.387128.094129.0575.001Diet
Basophils (K/μL)8UNC15749745128.714128.196129.1144.137Diet
Neutrophils (%)7UNC1247820019.07318.32319.9464.436Diet
Neutrophils (%)9JAX0017216064.40663.9764.6125.228Diet
Neutrophils (%)11JAX0031935097.40797.0498.5944.212Diet
Lymphocytes (%)1UNC2153593168.407134.457168.5234.474Diet
Lymphocytes (%)3UNC6271423132.468131.032132.7214.856Diet
Lymphocytes (%)7UNC1247820019.07318.32319.9464.087Diet
Monocytes (%)1UNC2064059161.322161.059163.9684.815Diet
Eosinophils (%)4backupUNC040653449114.54109.216114.7694.507Diet
RBC (M/μl)8JAX0067338378.50378.1178.7335.201Diet
Hb (g/dL)8UNC1508247980.32579.38185.6484.328Diet
Hb (g/dL)16UNC2667641039.15738.15440.0023.927Diet
Hb (g/dL)19UNC3045503750.48249.57953.4574.195Diet
HCT (%)3UNC549239571.2859.87572.8224.423Diet
HCT (%)6UNC12005865123.78122.635124.974.057Diet
HCT (%)9JAX0069563760.23960.10760.9354.449Diet
HCT (%)12UNC21982408116.81857.91117.0894.991Diet
HCT (%)13UNC2231187726.98126.0827.1364.386Diet
HCT (%)19UNC3039472046.36546.32646.5443.808Diet
MCV (fL)3UNC538743862.60160.802143.3534.825Diet
MCV (fL)5UNC945084572.972.78373.1164.134Diet
MCV (fL)6UNC06106418956.90856.63560.3784.895Diet
MCV (fL)7JAX0015295274.70474.37275.044.664Diet
MCV (fL)8UNC15545455114.683114.545114.8143.995Diet
MCV (fL)9UNC1613828134.27833.47934.8744.379Diet
MCV (fL)11UNC1990157672.47943.13472.8654.425Diet
MCV (fL)19UNC3042204448.1147.84948.1654.039Diet
MCHC (g/dL)2UNC304226051.28951.10251.7334.237Diet
MCHC (g/dL)4UNC8214230129.803124.7129.9025.752Diet
MCHC (g/dL)5UNC943072171.28770.85572.2255.287Diet
MCHC (g/dL)6JAX00146372124.953122.99124.974.616Diet
MCHC (g/dL)9UNC1647275561.31961.21865.6165.477Diet
RDW (%)11UNC11003293419.37318.95531.2244.39Diet
RDW (%)16UNC2654272428.02427.31728.0793.851Diet
PLT (K/μL)9UNC1611399432.62432.0333.5364.703Diet
MPV (fL)11UNC1928233226.1125.54326.9954.583Diet
MPV (fL)12UNC205585315.0023.60272.9644.801Diet
MPV (fL)17UNC2795159947.86847.76348.5824.015Diet
G0 (%)2UNC3678010104.217101.387105.5754.022Diet
G0 (%)18UNC1800030635.8415.38511.5544.034Diet
G1S1 (%)1UNC108636386.75675.71787.3764.863Diet
terminal Galactose (%)18JAX000800146.6855.38510.0354.176Diet
Galactose (%)2UNC354031593.73870.054105.5754.418Diet
Galactose (%)5UNC964971389.08888.589.2164.264Diet
Galactose (%)18JAX000800146.6855.38511.4094.707Diet
Sialic acid (%)1JAX0000620786.27685.76187.4114.318Diet
Sialic acid/Galactose 1UNC108636386.75685.76187.4114.197Diet
Mono-Galactose (%)18JAX000800146.6855.38510.0354.315Diet
IgA (ng/ml)7JAX0015030037.94237.45938.1954.866Diet
IgA (ng/ml)12JAX0032801525.52825.22725.6973.948Diet
IgA (ng/ml)14UNC2406762959.06858.68561.073.863Diet
IgM (ng/ml)4UNC8307892137.02625.859141.0675.144Diet
IgA/IgM7JAX0063639838.09637.30738.1954.228Diet
IgA/IgM12UNC2114455554.68154.356.0064.624Diet
IgAxIgG7JAX0015030037.94237.45938.1954.168Diet
IgAxIgG12UNC2149585582.1481.71482.4224.022Diet
IgA/IgM17UNC2830008571.76171.55372.0584.174Diet
Weight 6M (g)1UNC2404892188.91188.622189.0184.249Sex
Weight 6M (g)9UNC1656110168.5467.40369.0154.769Sex
Weight 6M (g)11UNC110186950116.156115.776116.2464.226Sex
Weight 6M (g)12UNC21895001111.475111.334111.8983.899Sex
Weight 6M (g)13JAX000412053.8993.1885.6664.176Sex
Cholesterol (mg/dl )2JAX0049318074.08573.54394.5525.251Sex
Cholesterol (mg/dl )XUNC3086183658.92258.1259.1283.722Sex
LDL (mg/dl)1UNC8785010.1489.84410.5554.363Sex
LDL (mg/dl)2UNC3868595122.229121.968122.9174.249Sex
LDL (mg/dl)XUNC3086100558.8038.47759.0714.665Sex
Weight 2M (g)1UNC2403310188.808188.622188.9544.274Sex
Weight 2M (g)6UNC105331858.5537.80613.044.19Sex
Weight 2M (g)7UNC1299554864.28662.80770.4044.783Sex
Weight 2M (g)8UNC141172238.4536.8849.7945.518Sex
Weight 2M (g)13UNC23355436110.292109.596110.5954.295Sex
Weight 2M (g)15UNC2604183386.96186.89187.4993.886Sex
Weight 2M (g)18JAX000798324.2423.244.5214.271Sex
Weight 2M (g)19UNC3027938337.79832.81238.2845.346Sex
Weight 4M (g)2UNC24955695.2983.6548.7045.122Sex
Weight 4M (g)13JAX000412664.7033.1885.6664.096Sex
Weight 6M (g)9UNC1655891268.33967.45569.0154.937Sex
Weight 6M (g)13JAX000412053.8993.5645.6664.809Sex
Steatosis11backupUNC1100002183.3553.3554.1454.282Sex
Steatosis18UNC2902083933.86933.59133.9134.243Sex
Ballooning1UNC2305100180.12179.764182.0024.27Sex
Ballooning10UNC1780987940.53438.71244.0434.737Sex
Ballooning11UNC20358363109.441109.367109.5294.097Sex
NAFLD2UNC3950499129.141128.91132.5964.073Sex
NAFLD10UNC1780987940.53438.91642.594.647Sex
NAFLD11backupUNC1100002183.3553.3554.1124.263Sex
CRP (pg/ml)1JAX00193766151.639150.9341524.354Sex
CRP (pg/ml)15UNC2548082044.46743.69348.3844.304Sex
CRP (pg/ml)13UNC23375979111.485110.741111.6844.658Sex
Neutrophils (K/μL)13UNC2278656068.88767.65169.2444.664Sex
Lymphocytes (K/μL)8UNC15565913116.038115.229117.3675.103Sex
Lymphocytes (K/μL)11UNC1918552718.2717.95118.8294.061Sex
Monocytes (K/μL)15JAX0039489818.86212.49421.1773.912Sex
Eosinophils (K/μL)7JAX00656104131.307129.993132.8254.434Sex
Eosinophils (K/μL)11UNC1966780355.57150.54856.1035.093Sex
Eosinophils (K/μL)12UNC21800440104.815104.21105.5433.816Sex
Basophils (K/μL)4UNC734135459.07455.8662.974.052Sex
Basophils (K/μL)7UNC13864984131.179129.539132.8254.293Sex
Basophils (K/μL)12JAX00344390104.851104.629105.5835.102Sex
Basophils (K/μL)15UNC2560881953.60450.7654.74.83Sex
Neutrophils (%)1UNC1543517120.953120.148121.3954.118Sex
Neutrophils (%)2JAX004820493.2343.1645.4794.09Sex
Neutrophils (%)7UNC13886290132.646130.968132.8953.93Sex
Lymphocytes (%)2JAX00501866123.575122.559123.9284.197Sex
Lymphocytes (%)7UNC1281598050.93550.42754.5424.179Sex
Eosinophils (%)14UNC2414488466.15464.99667.5753.818Sex
Basophils (%)15UNC2560881953.60450.7654.8395.301Sex
RBC (M/μl)16UNC2695636562.23256.19163.6044.954Sex
Hb (g/dL)8UNC1519198488.36787.85489.3784.521Sex
Hb (g/dL)16UNC2695636562.23261.28263.2664.427Sex
HCT (%)8UNC1519798788.81187.79789.6434.081Sex
HCT (%)12backupUNC12017028567.40158.533119.9744.139Sex
HCT (%)15UNC2608029989.97589.88190.1595.206Sex
HCT (%)17JAX0007748464.76563.16466.4284.817Sex
HCT (%)XUNC31320732131.11321.28134.3445.251Sex
MCV (fL)5JAX00134951119.971119.745120.0064.252Sex
MCV (fL)7UNC13688031116.899116.525117.1734.6Sex
MCV (fL)8UNC149905427372.39873.5724.326Sex
MCV (fL)9UNC1613884834.32333.38734.8744.454Sex
MCV (fL)11UNC190025065.0564.0055.5344.17Sex
MCV (fL)14JAX0005137129.27427.94529.4913.862Sex
MCV (fL)17UNC2779323933.26633.0938.3314.422Sex
MCV (fL)18UNC286552934.8694.5215.2654.668Sex
MCHC (g/dL)5JAX00134951119.971118.415120.0164.48Sex
MCHC (g/dL)7JAX0064649890.11289.75124.2385.201Sex
MCHC (g/dL)9UNC1646714160.93560.63372.7674.595Sex
MCHC (g/dL)14UNC24890760120.141116.462120.873.958Sex
MCHC (g/dL)16UNC2648042423.68423.59823.8064.181Sex
MCHC (g/dL)18UNC2895774629.2283.2432.1634.361Sex
RDW (%)3UNC6533297150.77150.5153.0424.874Sex
RDW (%)4UNC8235074131.451131.44131.5614.249Sex
RDW (%)6UNC1079408628.67125.33328.9514.3Sex
RDW (%)12UNC2075920626.29125.958105.7494.241Sex
MPV (fL)6UNC1117525359.33657.81264.0233.92Sex
MPV (fL)9UNC1687793092.76792.38694.4684.848Sex
MPV (fL)12backupUNC12017028567.40165.40567.774.209Sex
MPV (fL)18UNC2892146426.42726.22127.643.942Sex
G2S2 (%)5UNC950094876.5276.387136.9474.426Sex
G2S2 (%)7UNC13951822137.38137.348137.3874.881Sex
IgA (ng/ml)1UNC2210873172.57172.353172.8664.137Sex
IgA (ng/ml)5UNC85563204.8043.9738.1625.041Sex
IgA/IgM10UNC18692389109.553108.855109.7674.366Sex
IgA x IgG5UNC85563204.8044.0245.0154.942Sex
IgA/IgM10UNC18692389109.553109.017109.6034.366Sex
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